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This separation is important for regulatory compliance and patient safety, as it maintains independence between the commercial platform and the medical providers making prescription decisions

10.1002/mnfr.201700483 Mol Nutr Food Res

For instance, trypsin activity can decrease above 47C, resulting in prolonged hydrolysis and an ineffective release of peptides, while subtilisin exhibits stronger resilience to high temperatures and has been shown to affect the release of peptides (Rivero-Pino et al., 2021)

Sahiner M, Demirci S, Sahiner N